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Such molecular systems architectures have been successfully developed to reveal systems-level understanding of neurovascular disease ( Asthma is a chronic airway inflammatory disease with an allergic pattern of airway inflammation that is associated with airway hyperresponsiveness, mucus hypersecretion, and airway remodeling ( Genetic variations, environmental pollutants like tobacco smoke, particulate matter with a size of 2.510 microns, pest allergens, nitrogen dioxide, and ozone, respiratory tract infections, lifestyle disorders including vitamin D deficiency, obesity, effects of microbiome, and stress increase the risk of development of asthma ( Antigen-presenting dendritic cells (DCs) reside below the lung epithelial layer in the airway microenvironment

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