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Demyelination can impair neurological function, contributing to symptoms of mental fatigue, difficulty concentrating, and a general sense of being mentally 'foggy'all of which compound the physical tiredness

Saal HJ, Heerinckx F, Zawadzki R, Omidvar O, Kilpatrick M, Zesiewicz T (2018) Strong correlations among four measures of disease progression in Friedreichs ataxia