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Synthesis methods The analysis was done using Review Manager Software (RevMan 5.4.1, The Nordic Cochrane Centre, The Cochrane Collaboration, Denmark) under the inverse variance method

In animal models, NOD2 and Atg16l1 mutant mice exhibit specific immune cell composition and cytokine profile changes in a natural microbiome environment, directly demonstrating that both genetics and the environment jointly regulate gut immunity [245]

Liming Yang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers